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Pet Forum / Mammals / Rats / December 2004



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Sniffing Citrus Prevents Asthma in Rats

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paghat - 23 Dec 2004 18:15 GMT
Studies at by Professor Ehud Keinan & his team at Technion-Israel
Institute of Technology in Israel believe "natural ozone scavengers" such
as limonene in citrus fruits may prevent asthma. Their animal models for
the studies were rats.  As reported in the December 2004 Journal of
Bioorganic & Medicinal Chemistry, ozone in the body can cause inflammation
of cells, & the scent of citrus can neutralize the ozone. The rats in the
study first had asthma symptoms induced, then were treated with the citrus
odor, or inhalation of volatile hydrophobic olefins.

"The unsaturated monoterpene limonene, which is the main component in the
essential oil of citrus fruits, could thus function as an ozone scavenger.
In contrast, eucalyptol, a saturated monoterpene, which is an essential
oil of the eucalyptus tree, cannot scavenge ozone.  The experiments
involved exposing rats with asthma-like symptoms to either limonene or
eucalyptol for a couple of days before examining their lung function. The
pulmonary function of sick rats showed that limonene inhalation
significantly prevented the asthmatic symptoms while eucalyptol inhalation
did not alleviate the disease."

"The high environmental concentration of natural ozone scavengers in
agricultural areas could possibly now explain why the prevalence of asthma
in rural population is significantly lower than its prevalence in urban
population," proposes Professor Keinan.

So if you or your ratty are having an asthma attack, remember to sniff a lemon!

-paghat the ratgirl

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"Of what are you afraid, my child?" inquired the kindly teacher.
"Oh, sir! The flowers, they are wild," replied the timid creature.
  -from Peter Newell's "Wild Flowers"
Visit the Garden of Paghat the Ratgirl: http://www.paghat.com

Christopher Green - 23 Dec 2004 21:55 GMT
Except that beta-limonene is nephrotoxic to male rats (nobody's sure
why it's not toxic to female rats, but the toxicity in males is very
well known).

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Chris Green

paghat - 23 Dec 2004 22:20 GMT
> Except that beta-limonene is nephrotoxic to male rats (nobody's sure
> why it's not toxic to female rats, but the toxicity in males is very
> well known).

d-Limonene if ingested in sufficient concentrations causes renal tumors in
male rats. Such concentrations are not usually achievable by eating fruit
per se; exposure is riskiest by injesting solvents with lemony scents, or
eating a great amount of orange peals & lemon peals.

However, the protective value for asthma was achieved by SMELLING it, so
no need to eat a bit of it.

> (nobody's sure
> why it's not toxic to female rats, but the toxicity in males is very
> well known).

Actually the reason IS well known. Male rats have protein metabolites
which females lack, & it is to these male-specific metablolites that
limonene bonds, leading to renal tumors. Some strains of rats do not have
these precise metabolites required, & those strains are unaffected by
d-LImonene.

However, there are lesser risks not restricted to males or to males with
2u-globulin.  d-Limonene is harmful to infant rodents in gestation,
causing delayed prenatal growth, & causes deformities in the skeletal
structure of rats, rabbits, & mice exposed prenatally. It has also been
found  to be potentially carcinogenic hamsters, setting up conditions for
pancreatic cancer. Some of these problems are doubtless also associated
with humans, but only if huge aboun ts of peels are eaten, or concentrated
solvents which would be labeled as toxic.

These are the reasons citrus is always left out of rodents' diets, but
again, the positive effect of nulifying harmful ozone in the body &
alleviating  asthmatic lung swelling is derived from sniffing, not  by
eating, the citrus. Not that any of this has practical value for pet
keepers; when rats get bad lungs it is NOT apt to be asthma. These new
findings are more likely to help asthmatic humans, & it is thanks to rats
that this health benifit for people was discovered.

-paghat the ratgirl

Signature

"Of what are you afraid, my child?" inquired the kindly teacher.
"Oh, sir! The flowers, they are wild," replied the timid creature.
  -from Peter Newell's "Wild Flowers"
Visit the Garden of Paghat the Ratgirl: http://www.paghat.com

Davo - 26 Dec 2004 23:49 GMT
OK... Token is in a bad way. She has been treated for mico but still has bad
days and we just got her weened off predisone for the second time.

Should I buy a lemon sented car freshener or grate lemon peals in her
litter????????
Tracey - 27 Dec 2004 10:27 GMT
> OK... Token is in a bad way. She has been treated for mico but still has bad
> days and we just got her weened off predisone for the second time.
>
> Should I buy a lemon sented car freshener or grate lemon peals in her
> litter????????

Sorry to hear that.  Unfortunately the citrus oil only seems to alleviate
asthmatic respiratory problems, so wouldn't help a rat suffering from myco.
If you want to try something buy some essential oils of eucalyptus and tea
tree.  Burn a few drops of each (with a little water) in an oil burner near
the rats' cage.  I've found this often helps if the rats are struggling with
their breathing.

Tracey
Davo - 27 Dec 2004 23:53 GMT
Thanks Tracey:

I tried grating an orange peal and wiped her cage but miss fussy didn't
like it and refused to go back
to her cage until we cleaned it. She is having a good day today (Phew)......

> > OK... Token is in a bad way. She has been treated for mico but still has
> bad
[quoted text clipped - 11 lines]
>
> Tracey
Tracey - 28 Dec 2004 10:18 GMT
> Thanks Tracey:
>
>  I tried grating an orange peal and wiped her cage but miss fussy didn't
> like it and refused to go back
> to her cage until we cleaned it. She is having a good day today (Phew)......

They can be fussy little things can't they, lol!

Have you heard about the benefits of feeding a little chocolate to rats
suffering respiratory distress?
http://spazrats.tripod.com/chocolate.html

Tracey
Keith Schiffner - 28 Dec 2004 14:01 GMT
>> Thanks Tracey:
>>
[quoted text clipped - 11 lines]
> suffering respiratory distress?
> http://spazrats.tripod.com/chocolate.html

Oh that does SO work. BTDT...shared a cup of pudding with
mine once when he'd a nasty URI. That and a bunch of socks
fresh out of the dryer had him almost normal the next day.

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Keith Schiffner
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