> Except that beta-limonene is nephrotoxic to male rats (nobody's sure
> why it's not toxic to female rats, but the toxicity in males is very
> well known).
d-Limonene if ingested in sufficient concentrations causes renal tumors in
male rats. Such concentrations are not usually achievable by eating fruit
per se; exposure is riskiest by injesting solvents with lemony scents, or
eating a great amount of orange peals & lemon peals.
However, the protective value for asthma was achieved by SMELLING it, so
no need to eat a bit of it.
> (nobody's sure
> why it's not toxic to female rats, but the toxicity in males is very
> well known).
Actually the reason IS well known. Male rats have protein metabolites
which females lack, & it is to these male-specific metablolites that
limonene bonds, leading to renal tumors. Some strains of rats do not have
these precise metabolites required, & those strains are unaffected by
d-LImonene.
However, there are lesser risks not restricted to males or to males with
2u-globulin. d-Limonene is harmful to infant rodents in gestation,
causing delayed prenatal growth, & causes deformities in the skeletal
structure of rats, rabbits, & mice exposed prenatally. It has also been
found to be potentially carcinogenic hamsters, setting up conditions for
pancreatic cancer. Some of these problems are doubtless also associated
with humans, but only if huge aboun ts of peels are eaten, or concentrated
solvents which would be labeled as toxic.
These are the reasons citrus is always left out of rodents' diets, but
again, the positive effect of nulifying harmful ozone in the body &
alleviating asthmatic lung swelling is derived from sniffing, not by
eating, the citrus. Not that any of this has practical value for pet
keepers; when rats get bad lungs it is NOT apt to be asthma. These new
findings are more likely to help asthmatic humans, & it is thanks to rats
that this health benifit for people was discovered.
-paghat the ratgirl

Signature
"Of what are you afraid, my child?" inquired the kindly teacher.
"Oh, sir! The flowers, they are wild," replied the timid creature.
-from Peter Newell's "Wild Flowers"
Visit the Garden of Paghat the Ratgirl: http://www.paghat.com