Hello, I'm hoping someone can help me get a handle on what's wrong
with my dog. This is a lengthy post, but I want to put down the
entire medical history that I know.
I have a 13 and a half year old Dalmatian who was diagnosed with GME
over 3 years ago. The GME diagnosis was made by elimination, after an
MRI, brain stem tap, etc. Initially, she was put on a heavy dose of
prednisone, which eventually controlled the neurological symptoms she
was experiencing. The prednisone was then tapered to a much lower
dose. Two times since then the symptoms worsened, which were again
controlled by increasing the prednisone dosage. For the last nearly 2
years she has been on a very low dosage of prednisone -- 5mgs every
third day -- and has not exhibited the GME symptoms (pronounced
imbalance, etc).
Over the last year and a half, she has exhibited typical symptoms of
arthritis. She has become weak in her hips, drags her feet on
occasion (particularly when tired), and "dips" at the rear if she has
to stand still for long. Her hips and spine were x-rayed, and was
determined to be basically orthopedically sound, with little
indication of arthritis (though I was told she had a "mild form of
arthritis"). She has become slowly more symptomatic, but is still
able to go for walks and, although hampered in her range of motion and
abilities, does not seem to be in pain. It was recommended that I put
her on rimadyl, but I have not, because of the lack of pain and
potential side-effects, particularly in combination with the
prednisone she still takes.
She had blood work done about 6 months ago, to monitor any long-term
effects of the prednisone, which indicated some kidney degradation (I
was told that this is normal in older dogs and hers was slighlty worse
than a dog would be if it were not on prednisone), but otherwise
basically normal indicators (other than an atypical white blood count
that indicated an infection -- that was cleared up with antibiotics).
6 weeks ago she exhibited pronounced head tilt, loss of balance, and
nearly constant panting. I was advised to do nothing for a few weeks
to see if it went away on its own, due to geriatric vestibular
disease. Indeed, the extreme tilt, balance issues, and panting did
resolve themselves, but a constant, though minor, head tilt remains
still.
In spite of all of these issues, she was basically stable and had a
good quality of life until a new problem arose just a few days ago.
Lately, she has had problems sleeping at night, apparently due to
stomach issues. More specifically, although she has been normal in
the days, and sleeps in the early evening when we watch tv or read,
about the time we go to bed she becomes extremely restless and
agitated. She paces around the house and lies down for a few moments,
only to spring up and pace again. Also, these bouts are accompanied
by heavy panting, even though it is not hot here at all. This can go
on for several hours. During these episodes, I have listened to her
stomach, which makes a great deal of digestive noises. A few nights I
was able to calm her by giving her some food and a Pepcid, then
calming her to rest.
Last night, however, she was inconsolable. She was panting and pacing
constantly. I tried to feed her some, and had given her a Pepcid
several hours earlier. She did this on and off all night, culminating
in pooping and peeing in the hallway (she had been walked just before
we went to bed, as usual).
Does anyone have any ideas on what is going on with her, and what we
might consider doing next?
I really appreciate everyone's ideas and help. Thank you.
buglady - 24 Aug 2004 18:33 GMT
For the last nearly 2
> years she has been on a very low dosage of prednisone -- 5mgs every
> third day -- and has not exhibited the GME symptoms (pronounced
[quoted text clipped - 7 lines]
> Does anyone have any ideas on what is going on with her, and what we
> might consider doing next?
........After long term use of pred, I'd have a test run for Addison's
disease. Granted there could be a lot of other things going on, but hind
end weakness, panting, pacing, diarrhea were all symptoms my 10 year old lab
showed. It went undiagnosed until she went into crisis.
buglady
take out the dog before replying
Spot - 25 Aug 2004 00:41 GMT
As Buglady suggest here to have her checked for Addison. But I would also
like to point out that restlessness and inability to get comfortable can be
signs of pain. You said the vet suggested Rimadyl which wouldn't be a
problem except as you noted she is on prednisone and the two together don't
work all that well sometimes. There are other pain medications she can be
given besides Rimadyl or Deramaxx. If the testing for Addisons is negative
you might ask about a narcotic pain medication instead of the Rimadyl and
see what results you get from that.
Celeste
> For the last nearly 2
> > years she has been on a very low dosage of prednisone -- 5mgs every
[quoted text clipped - 16 lines]
> buglady
> take out the dog before replying
Bob - 27 Aug 2004 11:57 GMT
> As Buglady suggest here to have her checked for Addison. But I would also
> like to point out that restlessness and inability to get comfortable can be
[quoted text clipped - 6 lines]
>
> Celeste
Thanks for the responses and suggestions. I took her to the vet the
day of my original post (3 days ago) and he believes the current
symptoms are a sign of hypermotility, and prescribed Lomotil and put
her on Hill's I/D food for now. The basic idea is that he thinks it's
agitated digestion/bowels that are at the root of her odd behaviors.
Given the bowel/stomach noise heard on the first day, this seemed
reasonable.
After 3 days, I disagree with the diagnosis. She continues to exhibit
the same Dr. Jekyl/Mr. Hyde behaviors: during the day, she is normal
which, for her, means not terribly active, but comfortable,
affectionate, attentive. Only at night -- more specifically, only
after we go to bed at around 11pm -- she becomes a different dog. She
paces around the house ALL night long, pants heavily, and if not taken
out for a walk will pee/poop in the house (which I believe is
occurring because she is so worked up). She is inconsolable. She is
agitated and high strung. She continues this behavior until nearly
morning, at which point she is completely exhausted. Again, she is
fine until we go to bed. Indeed, she rests/sleeps or hangs out as
normal all evening, until we go to bed.
It seems unlikely that her behavior is due to pain -- that would be
relatively evenly distributed in the day and at night, and wouldn't
have an onset sharply when we go to bed. I'm at a loss and the vet is
no help.
Please help if you have any suggestions. She, and we, are miserable.
buglady - 27 Aug 2004 14:28 GMT
Only at night -- more specifically, only
> after we go to bed at around 11pm -- she becomes a different dog. She
> paces around the house ALL night long, pants heavily, and if not taken
> out for a walk will pee/poop in the house (which I believe is
> occurring because she is so worked up). She is inconsolable. >
> Please help if you have any suggestions. She, and we, are miserable.
.......I had to look up GME as I'd never heard of it. If this is what your
dog actually has (and it seems there's no definitive way to tell, even if a
spinal tap is done), then she's done pretty well over the years and you may
just be coming to the end of her journey. For a large dog 13 1/2 is pretty
elderly and at a certain point all of us face the time when there is nothing
else we can do. I'm not saying give up on her, but it helps at least to
think about the possibility beforehand, and plan for it also.
.....a question - do you feed her only at night or 2 times a day? Is there
anything different you feed at night?
.....i think because of the pred use I'd still check for Addision's disease
just to rule it out. Having had an Addisonian that ended up in crisis, this
is always on my mind. ;-)
But here's some simple things you can try at home first.
.......Does she sleep in the same room as you at night? If so could you
stand having a light on while you sleep? I've started leaving a light on
for my old kitty in her room. I think it's just a form of old brain and
fading eyesight, but she sometimes wakes up at night and complains - I think
she doesn't know where she is momentarily and maybe more importantly where I
am. There is something that occurs in very elderly people called
sundowner's syndrome - after sun goes down agitation goes up. It's a form
of old age dementia.
http://www.suite101.com/article.cfm/elderly_caregiving/5018
....I started to wonder if melatonin would help and it seems there might be
some efficacy and in fact some Drs. use it in nursing homes:
http://www.amda.com/caring/january2004/sleep.htm It might be worth a try.
Melatonin secretion is highest at night. You'd give it to her before she
starts to get agitated in the evening. I think the most standard dose you
find out there is 3 mg and wouldn't be inappropriate for a dog this size.
Some people have used melatonin for thunderstorm phobia. (check the archives
of this group at Google Group.) There was even a vet journal article about
it several years ago. And I wouldn't combine it with leaving the light on
all night. Try a light tonight and see if it helps.
Some of these suggestions for elderly people can be tried with dogs too:
http://www.amda.com/caring/january2004/sleep.htm
If she's not very active, talk to her when you go by her to keep her awake
more during the day. Take her for a ride in the car. Drive her to the park
and sit on a bench for a while. Do grooming and sit next to her while
you're watching TV and pet her. Anything to keep the stimulation up during
the day a bit. If it's not horrendously hot make sure she goes out in the
sun every day for a while. Perhaps even a doggy massage just before
bedtime. Going to bed should be a low key event. No stimulation just
before bedtime.
........Stress always uses up B vitamins and it might even help to toss a
B50 complex into her food once a day. Bs are very important in so many
processes in the body. They're water soluble and you're in no danger of
overdosing your dog with one a day as toxicity is very low.
.check the Senior Dog's Project: http://www.srdogs.com/ for helpful
hints. I had a lab make it to 14 1/2 but by that time she'd go stand with
her head in a corner a couple of times a day. I think it was old dog brain
and she was temporarily *lost.*
good luck with your oldster
buglady
take out the dog before replying