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Pet Forum / Miscellaneous / Animal Health / May 2005



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Did Prednisone kill my cat or was it inevitable?

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Deep Thought - 25 May 2005 12:19 GMT
We had owned/cherished our cat since it was a couple of weeks old and she
would have been 14yrs old in late August.... 18mths ago she was found to
have higher than "normal" calcium levels in blood. We had
prompted the test as we had noticed she was more frequently drinking.... our
long-standing veterinary practice believed that she was likely to have a
tumour somewhere and we agreed to bring her in for blood tests at a more
regular interval (2/3 months). Kidney readings were within acceptable levels
we were told. The calcium levels was a little higher on next test (normal is
I gather 2.83 m/mols - she was around 3.01 m/mols) - so at the vets
suggestion she was put on a fluid drip for the day to bring the level down.
Her most recent blood test was 10 days ago (this was routine check - her
behaviour was normal although the first had increased compared to couple of
months prior) - vet detected calcium levels of 3.70! (Apparently this is
getting very high). Also a small lump was felt in her abdomen area - this
may have been coincidence but vet considered that it was likely to be
tumour. We were advised that if this was abdomen tumour she would be
inoperable and were to prepare ourselves for the worse. The vet immediately
prescribed daily 5mg Prednisone and advised this would address the calcium
issue and also slow down the tumour growth - in other words make her feel
better. The next 4 days our cat took a
serious dive in her well-being - more than coincidence this was the period
the prednisone had been applied. She was sick a couple of times, was visibly
losing weight, lost appetite, lethargic, looked "out of it"... on the 4th
day we got her back to vet who could no longer feel the lump and her calcium
levels appeared normal again! - this seemed ununsually fast response to the
prednisone and the vet seemed to agree but said it was possible. However our
cat was now gravely ill which did not make sense to me. They x-rayed her but
no tumour could be seen (I understand that x-rays are not very reliable) -
she was given valium to sedate her for the x-ray but where they expected her
to become very hungry in response to valium she was not eating anything.
They kept her on drip overnight to try and get her fluids up. The next day
there was no change and she was ultimately put to sleep our arms at the
urging of the vet.
This has emotionally destroyed myself and my partner and has left me with a
feeling if having poisoned my own cat. The last blood tests indicated
"problems" with liver, kidneys and bone marrow - she was also anaemic...
essentially it appears her whole system had caved-in. Vet had suspected
lymphoma in early diagnosis and I suppose this remains a possibility. But
the whole situation turned upside down during the prednisone period and the
vet insists coincidence but I cannot accept that.
buglady - 26 May 2005 13:03 GMT
> We had owned/cherished our cat since it was a couple of weeks old and she
> would have been 14yrs old in late August.... 18mths ago she was found to
> have higher than "normal" calcium levels in blood.

words make her feel
> better. The next 4 days our cat took a
> serious dive in her well-being - more than coincidence this was the period
> the prednisone had been applied.

> This has emotionally destroyed myself and my partner and has left me with a
> feeling if having poisoned my own cat.

........I'm sorry you lost your long time friend.  At 14 years virtually
anything is possible.  The only way you would know for sure is if you had a
necropsy done.  Pred is often used for palliative care in cancer.  Cats
usually tolerate pred better than dogs.  In short, there's no way to know
now what went on.  The best you can do is honor your kitty's gift of love to
you and try to let the rest go.

My condolences
buglady
take out the dog before replying
ThePetAlchemist@FastMail.FM - 27 May 2005 00:05 GMT
HOWEDY bugF'nNUTS,

> > We had owned/cherished our cat since it was a couple of weeks old and she
> > would have been 14yrs old in late August.... 18mths ago she was found to
[quoted text clipped - 19 lines]
> buglady
> take out the dog before replying

Seems there's a lot of critters havin bad reactions to steroids...
GETOVER IT is what a vet would say to avoid gettin sued for
MALPRACTICE. Of curse, he wouldn't KNOW in advance the
critter is gonna react like that, but sometimes they DO.

Just GET OVER bein so DEFENSIVE of vets.

And then ask him HOWE COME he didn't UNDERSTAND that.

The Amazing Puppy Wizard <{) ; ~ ) >
ThePetAlchemist@FastMail.FM - 27 May 2005 01:06 GMT
HOWEDY bugF'nNUTS,

> > We had owned/cherished our cat since it was a couple of weeks old and she
> > would have been 14yrs old in late August.... 18mths ago she was found to
[quoted text clipped - 19 lines]
> buglady
> take out the dog before replying

But you knew that anyHOWE:

From: "buglady" <buglad...@bigfootdog.com>
Date: Sat, 30 Mar 2002 20:27:33 -0500
Subject: Re: Causes of Pancreatitis in Dogs

Diane D. wrote in message <3ca5f84...@news.mdc.net>...

>I am assuming that the Prednisone is the
>Corticosteroids.  Is that correct?

....Yep.

>Seems strange at so low a dose (5mg) don't you think in such a large dog?

...More from Sm An Clin Nut:

*Anecdotal reports suggest that corticosteroids are
the more common drug associated with pancreatitis in
dogs.

Pancreatitis is common in dogs with hyperadrenocorticism
Cushings) and in dogs receiving corticosteroids for
management of intervetertebral disk disease.

Experimentally, corticosteroids increase the sensitivity
of dispersed acinar cells to cholecystokinin and simulate
proliferation of the pancreatic ductular epithelium.*

........So the listing of intevetebral disk disease
being a risk factor is not really true - its a dog
with this disease on corticosteroids that is a risk
factor.

.......Additionally they say about the table I posted:

*Most animals with these risk factors, however, do not
develop pancreatitis.

An association has been made between hyperlipidemia and
acute pancreatitis in dogs and people, which has led to
speculation that disturbances in lipid metabolism may
be involved.

The exact relationsihp is not known in dogs or
cats and information is often extracted from
human cases.*

> She is now on a tranquillizer, has had plasma, only
> vomitted once last night and once this AM and seems
> much quieter.

......Glad to hear she's feeling a bit better.  As
long as she continues to improve, even a little, day
by day, you'll make it out of the woods.  I knew a
vet once that suggested subQs with pancreatitis, but
not enough to fully hydrate the dog until the vomiting
had stopped.  He said even with subQs if you pushed a
lot of fluid it somehow engaged the vomiting reflex.

Don't know if this is standard practice or not.

buglady
take out the dog before replying

From: "Diane D." <d...@pntcom.com>
Date: Sat, 30 Mar 2002 09:12:14 -0500
Subject: Causes of Pancreatitis in Dogs

I have a 10 year old female Pointer who is now in
Intensive Care with sudden onset Pancreatitis.

She has not eaten anything poisonous or received any
'special treats' which are the normal causes of this
disease. She has been on 500 mg. of Clavamox twice a
day for 3 days before the illness struck as well as
5mg Prednisone (weaning dose).

Could either of these meds have caused this to ocurr?

From: "buglady" <buglad...@bigfootdog.com> -
Date: Sat, 30 Mar 2002 10:53:34 -0500
Subject: Re: Causes of Pancreatitis in Dogs

Yes, corticosteroids are a risk factor for pancreatitis.

Small Animal Clinical Nutrition, 4th Ed. p. 788

Risk factors for pancreatitis in dogs and cats:

Breed:  Briard, Himalayan cat, Miniature schnauzer, Sheltie
Diet:  dietary indiscretion, high-fat, low-protein foods
Drug administration:  Azathioprine, Corticosteroids, L-asparaginase,
Organophosphate insecticides (cats)
Fasting hyperlipidemia
Gender:  castrated males, spayed females
Hepatobiliary disease:  Feline suppurative cholangiohepatitis
Hypercalcemia:  hyperparathyroidism, Intravenous calcium infusion
Increasing age
Intervetebral disk disease
Ischemia or reperfusion:  Postgastric dilation-volvulus
Obesity

buglady
take out the dog before replying

Diane D. wrote in message <3ca5ca5...@news.mdc.net>...

> She has been on 500 mg. of Clavamox twice a day for
> 3 days before the illness struck as well as 5mg
> Prednisone (weaning dose).  Could either of these
> meds have caused this to ocurr?

Date: Sat, 30 Mar 2002 12:28:05 -0500
Subject: Re: Causes of Pancreatitis in Dogs

Thank you for the article buglady!

I am assuming that the Prednisone is the Corticosteroids.
Is that correct? Seems strange at so low a dose (5mg)
don't you think in such a large dog?

Anything is possible I guess.

She is currently much more comfortable after removal of
the morphine patch - bad reaction that that - she
became "disuphoric" (not sure if that is the correct
medical term).

They have discontinued use of ampicillin in her IV
as they were concerned about the continued vomitting.
She is now on a tranquillizer, has had plasma, only
vomitted once last night and once this AM and seems
much quieter.

She is still running a low-grade fever.  No signs of
infection - could still be the lingering affects of
the morphine or ampicillin.

This is rather heart wrenching to watch in a dog that
has been very active and healthy for 10 years!

Thanks again for your help.

From: "Diane D." <d...@pntcom.com> -
Date: Sun, 31 Mar 2002 11:41:19 -0500
Subject: Re: Causes of Pancreatitis in Dogs

It is not looking better today for the girl.

She hasn't vomitted now for 24 hours, and seems much
brighter and alert, however her clotting time is
longer and there is concern about a lump in her
abdomine.  They have given her a dose of what they call 'special K' to
help with the clotting, she also
received more plasma and she is supposed to have an
ultrasound tomorrow. There is concern over a possible
tumor being the cause of all her symptoms.  Will know
more tomorrow.
 
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