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Pet Forum / Miscellaneous / Animal Health / June 2005



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need help with cancer diagnosis in my dog:

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davidgravina@gmail.com - 15 Jun 2005 07:48 GMT
My 9yr old schipperke just had a tumor removed from the front leg.  Vet
told me it is very difficult to get tumor this size removed from
extremities with any margin so it will likely re-appear she said
radiation may help but was very vague about what I should do from
here..

Here is the info from the lab report from a full histopathology.  If
you can offer any advice I would appreciate it.

description:
the mass is large lobulated nonencapsulated and is composed of loose
and dense areas of atypical mesenchymal cells arranged in whorls and
aplisades in the subcutis.  These cells vary from spindle to polygonal
with moderate amounts of eosinophilic cytoplasm.  Nuclei are rond to
oveal with one to two ditinct nuclei  and finely fnaular chromatin.
mitotic figurs are approx 3 per 1o 400x fields.  tumor cells extend to
surgical margin.

microscopic findings: nerve sheath tumor (low grade malignancy)

comments: nerve sheath tumors are locally agressive with high potential
for local recurrence following incomplete excision.  Tumor cells extend
to surgical margin.  surgical excision with 1 to 2 mm margins is
recommended if possible.
Ebbtide - 15 Jun 2005 08:01 GMT
> My 9yr old schipperke just had a tumor removed from the front leg.  Vet
> told me it is very difficult to get tumor this size removed from
[quoted text clipped - 20 lines]
> to surgical margin.  surgical excision with 1 to 2 mm margins is
> recommended if possible.

By the time the tumor is found there is usually metastasis. We recently
experienced this with our 8 y/o Black Lab. - rear leg. after I did some
research we opted not to do anything. He did well for 6 mos. We took him to
our summer place in the mts. He ran and swam, just had a good time. The last
month he lost wt.,(18# total) stopped eating and drinking.  The tumor
increased rapidly. It was not a pretty sight. We did what we knew he wanted,
we put him to sleep.It almost killed me. Please be considerate of your best
friend. Remember, animals don't understand treatment. I know the pain you
are going through.

Joyce and her new friend Bandit.
buglady - 15 Jun 2005 12:44 GMT
> > microscopic findings: nerve sheath tumor (low grade malignancy)
> >
> > comments: nerve sheath tumors are locally agressive with high potential
> > for local >
> By the time the tumor is found there is usually metastasis

.......not necessarily.  The above path report says they are _locally_
aggressive.  The surgeon did not get a clean margin (virtually impossible on
something like the leg where there's not much extra tissue) so the
likelihood of recurrence is greater.

......to  the OP - Google
nerve sheath tumor dog
There's probably a more technical name for this, but don't know it offhand
(ask your vet) and do some searching.  You may opt for amputation the next
time around if it recurrs.  I suspect this might be curative, but don't
know.  Don't be afraid of making your dog a tripod.  Dogs do well with only
3 legs and since your dog isn't a large breed and is most likely highly
agile, she will do fine.

If you have just tumor surgery done again in the case of recurrence you
might seek out an oncologist or someone who has dealth with this kind of
tumor on a leg before.  With mast cell tumors they found that the more
surgeries a person had done with that specific cancer, the lower the number
of local recurrences.  I think this had to do with taking wider margins,
which again, may be impossible on the leg.

In the meantime, feed good quality food and look into some antioxidants to
add to the food.  Supporting the body in any way you can is important.

Good luck to you and your pup
buglady
take out the dog before replying
Spot - 16 Jun 2005 03:07 GMT
I was thinking the same thing her that amputation may be the way to really
treat this before it gets far.  Dogs and cats alike do extremely well on 3
legs and adapt quickly.

I have cat who developed a giant cell tumor on the back leg roughly 9 weeks
after vaccination.  The first thought was the normal type tumor that appears
in some cases after vaccination.  I in her case it wasn't and it was very
aggressive.  My orthopedic said the only sure treatment for her was
amputation.  He told me if he could get it all and it hadn't spread to the
pelvic bones her chances of living a normal 13 years or more were great if
it had spread that far the he would simply close her back up and put her to
sleep.  She had surgery over 4 years ago and is still going strong.  Most of
the time no one even notices that she's ripping around on 3 legs till they
are here for a while.

Celeste

> > > microscopic findings: nerve sheath tumor (low grade malignancy)
> > >
[quoted text clipped - 29 lines]
> buglady
> take out the dog before replying
Carey Gregory - 15 Jun 2005 17:04 GMT
>By the time the tumor is found there is usually metastasis.

Are you sure your dog had the same type of tumor?  The pathology report
described it as "low grade malignancy" and everything I can find on the web
agrees.  It has a low metastatic rate.  For example:

Quoting from http://www.thensome.com/softissue.htm
# GENERAL fact sheet for soft tissue sarcomas
Soft tissue sarcomas (STS) are tumours arising from connective tissue
(mesenchyme other than bone) in middle aged to old dogs. They comprise about
15% of all skin tumours, and about 1% of all malignancies. The most common
histological types of STS are fibrosarcomas, haemangiopericytomas,
neurofibrosarcomas, schwanomas (also called malignant peripheral nerve
sheath tumors), and malignant fibrous histiocytomas. Excluded in this group
are tumours of haematopoietic or lymphoid origin and haemangiosarcomas.
Despite the different histological types, STS share similar characteristics:
# arise from any anatomic site in the body
# locally invasive
# recur after conservative excision
# low metastatic rate  <-------------------------- !!!
# poorly responsive to radiation therapy
***

So it's aggressive locally and prone to recur locally, but *not* prone to
metastasize elsewhere if it's treated.   Sounds like buglady's advice was
right on the money: remove it, and if it recurs, consider amputation.

>We recently
>experienced this with our 8 y/o Black Lab. - rear leg. after I did some
[quoted text clipped - 5 lines]
>friend. Remember, animals don't understand treatment. I know the pain you
>are going through.

With this I agree.
Josh - 20 Jun 2005 03:47 GMT
> By the time the tumor is found there is usually metastasis.

Nope.  Sorry, but that's wrong.  This type of tumor isn't that likely to
met.  The real problem with it is when it gets into the brachial plexus and
then the spine, which of course means surgery is taken off the table as an
option.  Depending on location, amputation is a valid choice.
Deborah, DVM - 16 Jun 2005 13:36 GMT
Treatment of choice for most tumors is to remove them.  If they are in a
location down on a leg where that cannot practically be done by routine
methods, you have 2 options -- amputate or seek ancillary treatment options
(i.e. chemo or radiation).  If you would consider chemo or radiation, then
you need to ask your vet to either talk to an oncologist for you, or refer
you to one.  Some tumors are very responsive to radiation, others aren't.  I
don't know about nerve sheath tumors.  The pathology report states that it
is "low malignancy" so I'd think that you might have good luck with either
local radiation, or radical surgery like amputation.  It sounds bad, but
dogs do great!  I recently amputated the hind limb on a small 10 yr old
poodle who had a mast cell tumor that had recurred and that we absolutely
could NOT get good margins on (it was down on her hock).  She did fabulous
despite her age, and once the hair regrew from the surgery site, you hardly
noticed she was missing that leg.

Good luck.

Deborah, DVM

> My 9yr old schipperke just had a tumor removed from the front leg.  Vet
> told me it is very difficult to get tumor this size removed from
[quoted text clipped - 20 lines]
> to surgical margin.  surgical excision with 1 to 2 mm margins is
> recommended if possible.
davidgravina@gmail.com - 17 Jun 2005 06:48 GMT
Hello Everyone,

Thank you so much for the advice and kind words.   My vet said that the
tumor is likely to grow back (since the margins were not clean) however
this type of cell tissue does not  metastasis in many cases.  Boo Boo
had blood tests and a full body x-ray with two views and everything was
normal and he has lots of energy so we are optimisitic the tumor has
not spread.

Also she consulted with the oncologist and called me back today.  She
said the oncologist only does chemo treatments (here in San Diego).
Radiation is quite effective with this type of tumor,  but it would
have to be done in a clinic in LA.  Basically I would have to leave him
there for 4 weeks of treatment and he would undergo general aneshesia
(for the treatment) 5 days per week.  I find this very difficult for
both me and boo boo.  He is always by my side and I don't think he
would handle this situation well.  Also, the treatment cost is about
5K, which is not something I had budgeted for so soon.  Finally, he is
a tough boy, but I think a full month of all this radiation and drugs
will take a toll on him.

The dr. did mention amputation last week, but she made it sound more
like a last resort if the tumor grows back quickly.

I have not completely decided yet but I am leaning toward just taking a
wait and see approach.  My vet also mentioned she recently operated on
a chow who had the same type of tumor cells removed from her leg and
the latency before re-growth was two years, which sounds encouraging to
me.

I just adopted Boo Boo from a rescue 3 weeks ago so I do not know how
long he had the tumor, how quickly it grew, or if he had previous
surgery.  The doctor seemed to imply the problem is more serious if the
tumor had been removed previously so I hope this is not the case..

Also, I may book an appointment with the oncologist here just to ask
her if there is anything else I can do besides the radiation to help
BooBoo stay healthy.  I started putting a little omega 3 fish oil on
his food (I use this also) as I read this may help prevent cancer
re-growth.  He seems to like the taste, and I would welcome suggestions
for antioxidants or other supplements that might be helpful.

I am feeding him the same food they used in the shelter: Science Diet.
I am not sure how this brand ranks as far as quality goes, but if you
can recommend something better, cost is not as issue for the little
guy.

Again, all your comments have been greatly appreciated.
Spot - 19 Jun 2005 17:59 GMT
David,

One thing you want to be certain to do in the eventuality that this leads to
amputation is to keep his weight in control and not allow him to gain any
excess.  It's better for him this way all around because he won't develop
joint problems later in life and if it comes to amputation it'll be easier
on him.

Celeste

> Hello Everyone,
>
[quoted text clipped - 44 lines]
>
> Again, all your comments have been greatly appreciated.
buglady - 21 Jun 2005 02:03 GMT
I started putting a little omega 3 fish oil on
> his food (I use this also) as I read this may help prevent cancer
> re-growth.  He seems to like the taste, and I would welcome suggestions
> for antioxidants or other supplements that might be helpful.

try www.dogaware.com for cancer links and discussion.

> I am feeding him the same food they used in the shelter: Science Diet.
> I am not sure how this brand ranks as far as quality goes, but if you
> can recommend something better, cost is not as issue for the little
> guy.

.......I'd feed canned food - more bioavailable than kibble.  Or toss some
fresh stuff in there a few days a week - like some tinned sardines or an
egg.

good luck with your pup and blessings to you for rescusing him
buglady
take out the dog before replying
davidgravina@gmail.com - 22 Jun 2005 21:15 GMT
Thank you Buglady.  I am sure he will like Sardines.  Also, can I feed
him the egg raw ?
buglady - 23 Jun 2005 02:02 GMT
> Thank you Buglady.  I am sure he will like Sardines.  Also, can I feed
> him the egg raw ?

.............sure; maybe some yogurt too.

buglady
take out te dog before replying
 
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