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Pet Forum / Miscellaneous / Animal Health / February 2007Mode of action of Rimadyl?
Anyone know the mode of action of Rimadyl? Could something like diabetes insipidus predispose a dog to an adverse reaction to Rimadyl? I know both are quite rare, and I also know that my dog's brother died after being given Rimadyl. Further, my dog may or may not (the jury's still out) have diabetes insipidus. Thoughts? Dale > Anyone know the mode of action of Rimadyl? > > Could something like diabetes insipidus predispose a dog to an adverse > reaction to Rimadyl? Dale, check the FOI section of the CVM. It's faster if you have the NADA number - check on the box. They should have the studies used for initial approval of the drug and might have mode of action. If not just google mode of action Rimadyl (or chemical name, which escapes me at the moment).. Or look at PubMed. FOI-Freedom of Information CVM - Center for Vet Med NADA - new animal drug approval. >> Anyone know the mode of action of Rimadyl? >> [quoted text clipped - 10 lines] > CVM - Center for Vet Med > NADA - new animal drug approval. Most of the sites I can find basically say we don't know the specifics of how it works... Was hoping maybe someone here might have something a bit more up to date/inspired. What made me wonder, is I know ADH activates ADH dependent adenylyl cyclase, which ramps up the cyclic AMP in the system. I know cAMP is a fairly generic second messenger.... sooo it may well be involved in the pathway for however caprofen (aka Rimadyl) works. I'm going to take a peek through the journal articles available through the university, and see what I can see. Dale > I'm going to take a peek through the journal articles available through > the university, and see what I can see. I had always heard that this was a drug they started using for humans and it had bad effects on the liver so they dumped it. There are some human studies available. Enter carprofen at PubMed, sort by date, then go to the end and work backwards. 7037867 - human 6111427 - kidney clearance 7452450 - metabolism of carprofen in rats/dogs/humans 15198222 - Cox 1 & 2/dogs/NSAIDs 11592333 - changes in hemostatic values in dogs I'd suggest going at it the other way - PubMed search for diabetes insipidus dogs. Found one interesting article associating gastrointestinal problems with polyuria - 12831107 ...happy reading buglady take out the dog before replying This is one on diabetes insipidus you might want to read: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Ab stractPlus&list_uids=8944803&query_hl=28&itool=pubmed_DocSum PubMed ID: 8944803 buglady take out the dog before replying Rimadyl is a COX 1 & 2 inhibitor -- it's effects are on the inflammatory cascade. I wouldn't think that diabetes insipidus would really have any impact. It's also primarily metabolized in the liver not the kidneys. Rimadyl is known to cause idiopathic acute hepatic failure which can lead to death. But this is a pretty unusual occurrence. Did the dog die from liver failure? If not then I doubt it was related to the rimadyl. (unless of course you had a bleeding ulcer -- that would be the other "side effect" of rimadyl -- or any NSAID -- that could lead to death). Diabetes insipidus can be secondary to pituitary tumors and other fairly significant diseases -- it can also look just like some pretty serious diseases -- so it's also possible that the dog died from that disease. The only other "link" between DI and rimadyl would be if the dog didn't in fact have DI but had primary renal disease -- in which case the rimadyl could potentially worsen the kidney disease. Deborah DVM > Anyone know the mode of action of Rimadyl? > [quoted text clipped - 8 lines] > > Dale > Rimadyl is a COX 1 & 2 inhibitor -- it's effects are on the inflammatory > cascade. I wouldn't think that diabetes insipidus would really have any [quoted text clipped - 3 lines] > death. But this is a pretty unusual occurrence. Did the dog die from liver > failure? Yep. That's what I was told by my guy's breeder when it happend. I'm not sure if the eventual necropsy bore out those findings, but that was the initial belief. The course of treatment for him was basically mild GI upset-->sulphonamide drugs-->developed stiffness-->Rimadyl-->liver failure I'm trying to look for a potentially connecting thread. Rather than two somewhat unusual things, one unusual thing with two different presentations. Boy I'm glad its reading week this week...the research continues. Dale |
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