Pet Forum / Miscellaneous / Animal Health / March 2007

http://immuneweb.xxmc.edu.cn/immune%20ppt/vic_vet_02.ppt.

1.3 Causes of Immune dysregulation

Stress
Toxins
Nutritional deficiencies
Hormones
Insulin
Infection, inflammation
Parasites
old Age

1.3 Causes of Immune dysregulation

Stress hormones (adrenaline, cortisone) act by blocking IL-12
(supressing TH1 cells), but stimulate APC's (antigen presenting cells)
and therefore stimulate TH2 cell production
Pesticides and heavy metals (environmental pollutants) supress TH1
cells

1.3 Causes of Immune dysregulation

Nutritional deficiencies created by improper diets, or by heavy
consumption of cooked processed foods, results in TH1 suppression.
Vitamins, which act not only as vital co-enzymes, but also as powerful
anti-oxidants and free radical scavengers, are intrinsic to immune
balance. As proteins, they are subject to denaturing during cooking,
and subtle damage can greatly reduce their bioavailability.
Vitamin E deficiency is directly linked to T cell-mediated immune
dysfunction

1.3 Causes of Immune dysregulation

Omega 3 Essential fatty acids are also heat sensitive, and create a
TH2 excess when deficient
Zinc deficiency directly results in TH1 suppression
Iodine deficiency leads to hypothyroidism, which causes T cell
deficiency
Chromium deficiency causes insulin resistance, which in turn leads to
excessive production of insulin, and excessive TH2 stimulation.

1.3 Causes of Immune dysregulation

Omega 3 Essential fatty acids are also heat sensitive, and create
a TH2 excess when deficient Zinc deficiency directly results in TH1
suppression Iodine deficiency leads to hypothyroidism, which causes
T cell deficiency

Chromium deficiency causes insulin resistance, which in turn leads to
excessive production of insulin, and excessive TH2 stimulation.

1.3 Causes of Immune dysregulation

There are 76 known macro and micro nutrients involved in homoeostasis.
Sub standard pet foods can contain as little as 38 of these nutrients.
Even top premium brand foods contain only 54.The full range of these
elements can only be found in raw,unprocessed, organic foods.

Probiotics in the large bowel play a key role in balancing TH1 and TH2

1.3 Causes of Immune dysregulation

Oestrogen and progesterone enhance TH2 expression, and suppress
Th1. This exaggerates allergies, but supresses tissue specific
autoimmune
disease (prevents foetal rejection). Eg worsens demodex Excessive
insulin production (high sugar intake, carbohydrates, insulin
resistance)
promotes TH2 expression.

1.3 Causes of Immune dysregulation

Many intracellular pathogens that infect macrophages can stimulate
production of IL-10, which results in TH2 stimulation, and TH1
suppression This results in suppression of the cellular immune
response, and
reduced clearance of the pathogen (eg FIV). Helminth parasites create
a strong TH2 response, leading to eosinophil activation and abundant
IgE.

Old age results in general depression of the TH1 response

1.4 Correcting Immune dysfunction

The key to treating the cancer patient is to stimulate the TH1 cells,
and suppress TH2 excess. The net result is to restore balance to the
immune system. There are several key nutrients that have this effect,
and a range of other nutrients that support tissue repair and correct
nutrient deficiencies

1.4 Correcting Immune dysfunction

Substances that stimulate TH1 cells, and / or suppress TH2 excess:

Perilla seed
Cat's Claw
Coriolus versicolor
Glutathione
Grifola frondosa
Phytosterols
Shark Liver Oil
Shitake mushroom
Vitamin E (low dose)
Zinc

1.4 Correcting Immune dysfunction

Substances that balance TH1 and TH2 :

Astragalus membranaceus
Bromelain
Pro biotic bacteria
Reiishi mushroom

1.4 Correcting Immune dysfunction

Perilla frutescens contains flavanoids called Luteolin.
Luteolin has been clinically proven to inhibit the release of
histamine, leukotrienes and prostaglandin from mast cells in a dose
dependent manner, by suppressing TH2 excess, and blocking IgE
formation

1.4 Correcting Immune dysfunction

Cat's Claw (Uncaria tomentosa) stimulates cellular immunity, and has
proven effectiveness against Mycoplasma, Rickettsia, Chlamydia, and is
showing promise in treating chronic immune deficiency disorders like
HIV and Herpes infection

1.4 Correcting Immune dysfunction

Coriolus versicolor (Karawatake mushroom), Grifola frondosa (Maitake
mushroom) and Lentinus edodes (Shitake mushroom) all act to enhance
proliferation of B and T lymphocytes, activate macrophages, memory T
cells, and stimulate natural killer T cells.

They also enhance the effects of chemotherapeutic drugs and reduce
damage to healthy tissue

1.4 Correcting Immune dysfunction

Plant phytosterols (sitosterol and sitosterolin) have been
demonstrated in numerous trials in South Africa, to be potent immune
balancers, both able to stimulate TH1 deficiency and suppress TH2
excess

Use has been focused on treatment of HIV infection, cervical and
prostatic cancers, allergic conditions, and rheumatoid arthritis with
consistent (>50%) improvements.

1.4 Correcting Immune dysfunction

Shark liver oil contains high levels of Alkylglycerols, as found in
bone marrow and breast milk.

They are potent stimulators of T cell counts and Natural Killer cells
alkylglycerols are currently being researched for their use in
treating HIV and immune supression

1.4 Correcting Immune dysfunction

Deficiencies of zinc, nitric oxide, or glutathione will cause a shift
towards TH1 deficiency, and TH2 excess

Deficiency of any of the essential nutrients methionine, cysteine,
arginine, vitamins A,B,C,E, zinc and selenium, which are utilised to
form Glutathione, nitric oxide and metallothionein , can lead to a TH1
deficiency

1.4 Correcting Immune dysfunction

Astragalus membranaceous balances the Th1/TH2 response.
It enhances phagocytosis and Killer T cell activity, increases T cell
counts, and reverses macrophage suppression it also demonstrates
anti-inflammatory and antihypertensive properties

1.4 Correcting Immune dysfunction

Probiotics provide for oral tolerance, by enhancing TH1 responses and
supressing TH2. The prescence of  probiotics in the bowel improve
intestinal function, enhance bioavailability of nutrients, decrease
the
prevalence of allergies, reduce symptoms of lactose intolerance, and
reduce the risk of certain cancers.

1.5 Substances that promote tissue repair and metabolism

Shark Cartilage powder, containing GAG's, accelerates tissue repair in
joint tissues, skin hair and nails, and the lining of the digestive,
respiratory, and urogenital tracts It also contains
antineoangiogenetic
factors that have been shown to slow the growth of certain solid
tumors

1.5 Substances that promote tissue repair and metabolism

Antioxidants like bromelain, quercetin, vitamins C, E, A,
betacarotene, grape seed extract, green tea, and pine bark extract are
all powerful free radical scavengers (induce superoxide dismutase
production), and provide for additional antioxidant protection
following surgery, chemotherapy etc.

1.5 Substances that promote tissue repair and metabolism

Colloidal minerals are the most easily assimilated form of nutrient
supplements.

They are in the liquid form, as found in plant cells, and are
passively absorbed across the bowel wall Colloidal complexes
contain all 76 known macro and micro nutrients

                       -----------------------------

                     Death Producing Ulcers:
     "Emotional Influences On Health & Behavior"
                  Dr. George Von Hilsheimer

       Illness is directly related to depression and lack of
       adjustment, particularly to a new environment (Parens,
       McConville & Kaplan, 1966).

       A WIDE RANGE of PSYCHOSOMATIC or
       CORTICOVISCERAL DIS-EASES was surveyed
       by Wittkower (1965) to demonstrate the enormous
       importance of emotional factors in general health.

       Interview findings of emotional material (recently
       experienced hopelessness) pryor to biological
       examinations correctly identified 11 out of 19 with
       cervical cancer, and 25 of 32 who were cancer free
       even though psychological tests failed to discriminate
       these groups (Schmale & Iker, 1966)

       150 lung cancer patients showed significantly
       constricted expression of emotions. The had fewer
       childhood behavior problems, and lower neuroticism
       score than their cancer free controls. Heavy cigarette
       smokers who DO NOT INHALE are more apt to have LUNG
       CANCER. They, too, show LOWER neuroticism scores.
       Among heavy cigarette smokers poor emotional
       expression is as highly related to cancer as urban
       residence and is more important than a chronic cough
       or an air polluted environment (Kissen, 1966).

       A ten year observation of all the women who developed
       cancer in an isolated pupulation of 2,550 showed that
       they tended to be unstable or sub stable personalities
       characterized by melancholy and extraversion,
       especially marked with those of an undecided body
       build (Hagll, 1966). Personality dynamics effect both
       the development of cancer and it's SITE. Cancer
       may result from what appears to be a failure to grow--
       somatically, behaviorally and psychologically
       (Grinker, 1966).

       In 109 cases leukemia and lymphoma were associated
       with a number of losses or separations and with
       feelings of sadness, anxiety, anger or hopelessness.
       The PRIMARY FACTOR seems to be the shame and
       hopelessness of running out of psychological resources
       (Green, 1966). Cervical cancer patients are less
       emotionally responsive, more isolative, and less
       frequently diagnosed as having clinical neuroses than
       cancer free patients. There is NO CLEAR DIFFERENCE in
       their FEELINGS and ATTITUDES toward coitus (Rotkin,
       Qunk, & Couchman, 1965).

       Schmidt (1966) surveyed nearly 100 studies of
       behaviorally induced DIS-EASE in animals CONFIRMING
       and EXTENDING the DATA on PEOPLE. Behaviorally
       induced DIS-EASES tend to fall into two groups;
       (1) Hysteriform problems, which INCLUDE HYSTERICAL
       SEIZURES and FORMS of AGGRESSION as well as
       collective panic and epilepsies;

       (2) organic modifications, including functional difficulties
       and lesions affecting gastro intestinal, cardio vascular,
       respiratory, sexual, endocrine, skin, urinary, and neuro
       muscular systems.

       It is INTERESTING, and SLIGHTLY HORRIFYING,
       to note that the ONLY SCIENTIFIC RELEVANCE of
       the standard six hour school day that I have been able
       to detect in research is that Sawrey and Weisz quite
       by accident found that six hours on and six hour off of
       "EXECUTIVE  BEHAVIOR" in monkeys was the ONLY
       TIME STRUCTURE that INDUCED DEATH PRODUCING
       ULCERS.

                    --------------------------------------------

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