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Pet Forum / Miscellaneous / Animal Health / April 2007Need some help in understanding these results...
I typed this verbatum but the faxed copy that I received had some words kind of thrown off. My 9.5 year old Alaskan Malamute - Keko - had his right eye removed over a week ago and these are the biopsy and histologic eval results. I've talked to our vet about it but I'm still a little foggy (and depressed) about it. I am having them do the additional test that the results recommends for a more definitive answer. Diagnosis: "Suspect tweet lymphoma, and hyperpignsentation - see comments" Comments: Histologic evaluation of sections of the globe reveal an infiltrative neoplasm arising within the wee, often effacing and expanding the iris and trabecular meshwork, and extending superficially into the retina. This mass is comprised at round cells, consistent with a lymphoma. There are frequent mitotic figures and thus, this is likely to represent high grade lymphoma. There are large areas of coagulation necrosis of neoplastic cells within the anterior chamber, consistent with the yellow material seen grossly. There are frequent melanin containing cells interspersed within the mass, consistant with pigmentary incontinence and phagocytosis of melanin by macrophages and rnelanocrte (sp?). The possibility of a melanoma cannot be completely excluded; however is thought to be less likely. It is advisable to perform 1B and T Cell irnmunohistochemistry in order to further define and confirm the diagnosis of lymphoma. any suggestions... recommendations... Thanks, Anthony & Keko... > My 9.5 year old Alaskan Malamute - Keko - had his right eye removed over a > week ago and these are the biopsy and histologic eval results. ........I'm so sorry. Nothing like the word cancer to turn off the brain cells. How's your pup doing now? I'm assuming that eye looked *not right*. Is he showing any other kind of symptoms - tiredness, vomiting, loss of weight, etc.? When will the other test results be in? For now, take a deep breath and resign yourself to wait for results. Read your eyeballs off in the meantime. You might think about consulting a vet oncologist too. A few links: A case of conjunctival lymphoma, which once removed, never reoccurred: http://www.blackwell-synergy.com/links/doi/10.1111/j.1463-5224.2005.04053.x/ abs/ General http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/30604.htm http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui ds=11373832&dopt=Abstract .......There's more to look at within links at right on above page. ............Also more to look at when I Googled: Ophthalmic neoplasm dog .........And veterinary ophthalmology > Diagnosis: "Suspect tweet lymphoma, and hyperpignsentation - see comments" ........that's possibly hyperpigmentation, don't know what tweet lymphoma could be. > Comments: Histologic evaluation of sections of the globe reveal an > infiltrative neoplasm arising within the wee, often effacing and expanding > the iris and trabecular meshwork, and extending superficially into the > retina. This mass is comprised at round cells, consistent with a lymphoma. > There are frequent mitotic figures and thus, this is likely to represent > high grade lymphoma. ......mitosis is cell division - a lot of cell division means it's fairly active .......neoplasm is basically cancer There are large areas of coagulation necrosis of > neoplastic cells within the anterior chamber, consistent with the yellow > material seen grossly. ......fast growing cancer cells sometimes outgrow their blood/food supply and the center of a tumor dies - necroses. There are frequent melanin containing cells > interspersed within the mass, consistant with pigmentary incontinence and > phagocytosis of melanin by macrophages and rnelanocrte (sp?). .......that's probably melanocite; don't know what melanin containing cells would mean; macrophage is part of the immune system, runs around and eats stuff. The > possibility of a melanoma cannot be completely excluded; however is thought > to be less likely. It is advisable to perform 1B and T Cell > irnmunohistochemistry in order to further define and confirm the diagnosis > of lymphoma. ..........I didn't look up melanoma and eye, might be worth a shot. ..........please post back and let us know what's going on. All the best to you and your pup. Give him a hug. buglady take out the dog before replying He seems to be doing okay, he's still getting use to losing the eye which seems to have him a little depressed. The eye, that all happened very suddenly. On Sunday afternoon I noticed he was squinting I looked at it and looked okay, Monday morning I looked again and there was mucous coming out and about a quarter of his eye was cloudy, called the vet and got an appointment for the next morning, then on Tuesday the entire was cloudy and still mucousy. Tuesday afternoon I saw the eye specialist who gave me the bad news, then on Thursday the eye was removed. My boy has been to hell and back a few times in the last 3 months. January I almost lost him to cholangial hepatitis, after a few weeks of intense care, force feeding, and whole lot of love he got better actually back to normal. Then in February he went through a few days of intense sneezing. With his fur he likes to lay down on the tile to keep cool, a few times while sneezing he smacked his head very hard on the tile which ended up bruising the nerve to his left eye and now has Horners Syndrome in that eye. The vet and eye doc said that it looks scary but he could see out of it normally and that over a period of time the eye will get better. Then in March he injured his back and had a lot of pain with that, so a few more weeks of intense caring, pampering, and of course a lot more special loving he healed up and was back to normal again. Having fun at the park, showing off on the play ground (he was trained in agility so he is fearless when it comes to obstacles). Then about a week and a half ago his right eye. Which comes to find out was lost because of cancer. I love my dog just as much as though he was my son. He and I have been through so much in the last 9.5 years and it's hard to imagine him not being with me. We use to cruise around him strapped in on the passenger side wearing our shades (he loved wearing them and acted as if he was so cool) and check'n out all the people. He is very handsome and no matter where we are at he always ends being the center of attention, women love him and kids love him. He's my 115lb furry teddy bear. This is the website that I started putting together for him (http://keko.themaskes.com/) there is only a few pictures right now but everyone can see how handsome he is... Anthony >> My 9.5 year old Alaskan Malamute - Keko - had his right eye removed over >> a [quoted text clipped - 71 lines] > buglady > take out the dog before replying Anthony, He is absolutely beautiful. I love huskys they are the greatest dogs. I had cat who lost an eye and he adjusted just fine, give him sometime he will adjust to. I hope all is well give the big furball a huge hug for me. Celeste > He seems to be doing okay, he's still getting use to losing the eye which > seems to have him a little depressed. [quoted text clipped - 113 lines] >> buglady >> take out the dog before replying Anthony I second that....he is absolutely 'gorgeous'! My prayers are with you & your beloved pup. In time after the healing he will be back to his old ways. His body has gone through some major changes but in time he will adjust. Seeing his gorgeous picture it was like seeing a ghost. We had the same (prince) malamute who lived for 12 years. He had the same coloring & the same long fur as your Keko. However he was 250lbs. Big as he was he was like a baby, spoiled rotten actually. He even had his own account with an ice cream truck who pass our house. :-) Please keep us updated with his progress & give him a hug from me as well. And let us know when you update his web site too. Take care........ Diane > He seems to be doing okay, he's still getting use to losing the eye which > seems to have him a little depressed. [quoted text clipped - 49 lines] > > A few links: > > A case of conjunctival lymphoma, which once removed, never reoccurred: http://www.blackwell-synergy.com/links/doi/10.1111/j.1463-5224.2005.04053.x/ > > abs/ > > General > > http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/30604.htm http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_ui > > ds=11373832&dopt=Abstract > > .......There's more to look at within links at right on above page. [quoted text clipped - 51 lines] > > buglady > > take out the dog before replying > I typed this verbatum but the faxed copy that I received had some words kind > of thrown off. [quoted text clipped - 27 lines] > > Anthony & Keko... This is basically a bad prognosis. This is diagnosed as a tumor of cells of the immune system (white blood cells or lymphocytes), that has an increased mitotic index (rapidly growing and likely metastatic), that is containing and releasing melanin ( a pigment of cells that is increased in cancers such as metastatic melanoma of the skin, very aggressive). Further testing will reveal a more definitive diagnosis of the type of cancer and whether it will be suspected of being metastatic (spreading). Thanks everyone..., we are now seeing and being guided by an Oncologist in Sacramento. Tuesday, he goes in for an MRI and some other testing. >> I typed this verbatum but the faxed copy that I received had some words >> kind [quoted text clipped - 45 lines] > diagnosis of the type of cancer and whether it will be suspected of > being metastatic (spreading). > Thanks everyone..., we are now seeing and being guided by an Oncologist in > Sacramento. Tuesday, he goes in for an MRI and some other testing. .......Good! Hug that pup every day and we'll have all paws crossed here for you. Please keep us posted. buglady take out the dog before replying Today his stitches come out from when he had his eye removed and tomorrow is the MRI with the neurologist. As of today, he isn't even able to stand up; when he tries it's like the floor is swept out from beneath him. I carry my 100lb baby every where (he's lost 15 lbs in the last 2 weeks). I am very fortunate to have a very understanding and sympathetic wife, I've been sleeping with him every night and hold him all night long. He seems to be able to relax more when he is in the comfort of my arms. >> Thanks everyone..., we are now seeing and being guided by an Oncologist >> in [quoted text clipped - 6 lines] > buglady > take out the dog before replying > Today his stitches come out from when he had his eye removed and tomorrow is > the MRI with the neurologist. ..........when you have time, let us know what's going on. > As of today, he isn't even able to stand up; when he tries it's like the > floor is swept out from beneath him. ......I wonder if it's only having one eye that is disorienting your pup, giving him a sort of vertigo when he turns his head? Or has he been weak since the surgery? buglady take out the dog before replying Hi, The status to date... first though, I'm not savvy with all the medical terms and such so some of this might not make sense... I had an MRI, bone marrow, and Spinal tap done on Keko, according to the neurologist the nerve stem endings connected to his brain are swollen, he believes this is what is causing the dizzy & unbalance problems. There were also signs of lymphonites in Keko's spinal fluid, apparently and as I recall his bone marrow was clear. Now the more detailed testing of is eye (I guess it's called "staining"?) came back positive for "T Cell Lymphoma", although Keko's lymph nodes are perfectly normal. I opted to start Prednisone a week ago and will now start chemotherapy starting next week. I am suspicious about a few things though. The dizziness and unbalancing didn't start until 3 days after Keko had his right eye removed. Following his eye surgery Keko mostly slept but had no problems walking in fact had no problems going up and down the stairs. I did notice that he was having problems chewing out of his right side (same side as the surgery). The dizziness / unbalance symptoms reached a certain point and stopped, he didn't get any worse but wasn't getting any better. The prednisone is slowly bringing back his mobility but with the aid of a few items such as booties (90% of my house is tile so he tends to slip - the booties are giving him more traction so he's able to balance himself better). The incision area over his eye never leaked any fluids, never turned pink or discolored for that matter, and appeared to heal fine. But, is it possible that when the eye was removed certain nerve stems became damaged other than what would be expected from the eye being removed that would be contributing to this dizziness/balance problem? I asked each doctor I spoke with and since he tested positive for T Cell Lymphoma they believe that this is the only cause of the dizziness/balance problems. It just seems to me to be a little to coincidental on how all this happened/occurred. As for Keko's spirits... He and I both started slowing down about 2 years ago, we'd go on walks and stuff but any rigorous running and/or pulling pretty much ceased. Other that not being able to jump up and run he seems to still be a happy dog, he seems more at ease and comfortable when I'm with him, he's been eating and drinking even before the prednisone. In fact, I was told that the prednisone will get him to want to eat more; but that hasn't been the case, some feedings he'll eat the entire bowl other feedings he will eat maybe half and that's it. >> Today his stitches come out from when he had his eye removed and tomorrow > is [quoted text clipped - 11 lines] > buglady > take out the dog before replying |
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