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Pet Forum / Miscellaneous / Animal Health / January 2008



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Digestive Enzymes and Weight Gain?

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Dale Atkin - 15 Jan 2008 22:22 GMT
As some of you already know, my 3 1/2 y.o. Lab has nasty arthritis in his
elbow, and an injured cruciate.

Needless to say, I'm trying to keep a very close eye on his weight. He was
up about 2 lbs from what I'd like him  to be at his last weigh in. His new
food (Royal Canin Mobility support) is calorie restricted, so I figured if I
continued to feed him the same amount (the bag actually recommends I feed
him much more than I am), the weight should 'take care of itself. I was a
little shocked today to find that since his last weigh in, not only has he
not lost any weight, HE'S GAINED 3 POUNDS! His activity level has stayed
comparable to what its always been.

The only thing I can think of, is one of the supplements I'm giving him
contains digestive enzymes along with everything else. Could this cause him
to gain weight? (i.e. he may be taking in less calories, but he's using them
more effectively now?)

Any other thoughts?

Dale
buglady - 16 Jan 2008 10:15 GMT
> As some of you already know, my 3 1/2 y.o. Lab has nasty arthritis in his
> elbow, and an injured cruciate.>
> Any other thoughts?

..........have you ever had a thyroid panel run?

buglady
take out the dog before replying
Dale Atkin - 16 Jan 2008 13:54 GMT
>> As some of you already know, my 3 1/2 y.o. Lab has nasty arthritis in his
>> elbow, and an injured cruciate.>
>> Any other thoughts?
>
> ..........have you ever had a thyroid panel run?

No, but his coat is absolutely gorgeous (I'm forever getting comments about
it). I would be very surprised if he had a thyroid issue on top of
everything else.

Dale
buglady - 16 Jan 2008 15:13 GMT
> >> As some of you already know, my 3 1/2 y.o. Lab has nasty arthritis in his
> >> elbow, and an injured cruciate.>
[quoted text clipped - 5 lines]
> it). I would be very surprised if he had a thyroid issue on top of
> everything else.

..........might be worth it though; cruciate ligament injuries can be a sign
of thyroid problems, coupled with the weight gain......well, you never know.
I consider this sort of test part of an investigative/learning process.

buglady
take out the dog before replying
Deborah, DVM - 16 Jan 2008 19:19 GMT
First, check the actual calorie content of current food vs old food.  You
can usually do that online at the company's website.  Make sure you aren't
actually feeding more calories.  Second, make sure no one else is feeding
him ;-).  Cat food out of reach, other family members not feeling sorry for
him, neighbors sneaking him treats across the fence....you get the idea.  If
no one else is feeding him, and if in fact you are feeding a lot less
calories, then it may be that he's too calorie restricted.  Rarely animals
can go into "starvation mode" when you abruptly cut back on calories.  Their
body thinks they are being starved, so every calorie they get goes directly
to fat.  So you sometimes have to actually feed more.  I'd also consider
looking into thyroid just as a precaution.

Deborah, DVM

> As some of you already know, my 3 1/2 y.o. Lab has nasty arthritis in his
> elbow, and an injured cruciate.
[quoted text clipped - 16 lines]
>
> Dale
Dale Atkin - 17 Jan 2008 04:27 GMT
> First, check the actual calorie content of current food vs old food.

Stangely, only the pet store food he was on has the calorie count indicated
on the company website (403kcal/cup). The veterinary diet he's on (Royal
Canin Mobility Support) doesn't have it indicated (I would have thought that
would be the other way around). I'm planning on calling them anyways, and
getting them to fax me some more detailed information about what exactly the
food contains. I'm sure that will have a calorie count on it, but given that
its marketed as "Calorie Restricted", and the recommended feeding according
to the bag is 6 cups/day (which I'm not giving him), I don't think he could
possibly be getting more calories than he was before.  (although the feeding
guide they have in the clinic suggests closer to 4 1/2 cups/day... I was
giving him 4 and a little tiny bit)

> You can usually do that online at the company's website.  Make sure you
> aren't actually feeding more calories.  Second, make sure no one else is
> feeding him ;-).

No one else will admit to it anyways :), except maybe my little nephew (18
months old), but he's not over often enough to make a difference.

> Cat food out of reach, other family members not feeling sorry for him,
> neighbors sneaking him treats across the fence....you get the idea.

Nearest neighbour is 150+m away, and he's never outside alone anyways. You
made me laugh with the bit about the cat food. I remember once about a year
ago, I left him in the car with a 6 lbs bag of cat food. The bag was burried
under a 4L jug of windshield washer fluid, my jacket, and goodness knows how
many other things. Add to that that it was unopened, and required him
squeezing through a space no more than about 8 inches wide, and down about 3
feet to reach it, and yet somehow when I can back to the car, he'd downed a
good 2 lbs of cat food. Needless to say, we generally keep the cat's food
well out of reach.

> If no one else is feeding him, and if in fact you are feeding a lot less
> calories, then it may be that he's too calorie restricted.  Rarely animals
> can go into "starvation mode" when you abruptly cut back on calories.
> Their body thinks they are being starved, so every calorie they get goes
> directly to fat.

Erwin's been secretly e-mailing you hasn't he :). (You know he's a lab
right? He's *always* in starvation mode if you ask him).

> So you sometimes have to actually feed more.  I'd also consider looking
> into thyroid just as a precaution.
>
> Deborah, DVM

I'll keep a close eye on his weight over the next couple of weeks. I've cut
down his food a bit. I figure K.I.S.S. is probably the best approach at this
stage. Chances are, his activity level has really changed more than I think
it has (I really don't think it should have changed enough to have him gain
a pound a week though, he still gets a walk every day, for a minimum of an
hour each time, but hey who knows right?). If the weight continues to go in
an unexpected direction, I'll suggest running a thyroid panel.

Dale

>> As some of you already know, my 3 1/2 y.o. Lab has nasty arthritis in his
>> elbow, and an injured cruciate.
[quoted text clipped - 16 lines]
>>
>> Dale
Suja - 17 Jan 2008 15:14 GMT
"Dale Atkin" <labrador1@ibycus.com> wrote in message:

> food contains. I'm sure that will have a calorie count on it, but given that
> its marketed as "Calorie Restricted", and the recommended feeding according
> to the bag is 6 cups/day (which I'm not giving him), I don't think he could
> possibly be getting more calories than he was before.

I'm not sure if 'calorie restricted' is supposed to have any sort of strict
definition.  You'd think that it means lower calories, but lower calories
than what?

> (although the feeding
> guide they have in the clinic suggests closer to 4 1/2 cups/day... I was
> giving him 4 and a little tiny bit)

That's A LOT of food.  I do not normally feed by any recommendations on the
bag, opting to go on the basis of look and feel.  Just so you know, Khan (87
pounds at a good skinny weight) eats 1 1/3 cups of Solid Gold WolfKing (364
Kcal/cup), plus some fillers to make him feel full (cooked up veggies,
mostly).  He's hypothyroid and Cushingoid, both of which can contribute to
weight issues, so if you can't resolve this by managing his diet, you may
want to look into endocrine issues.

Suja
Dale Atkin - 17 Jan 2008 15:24 GMT
> "Dale Atkin" <labrador1@ibycus.com> wrote in message:
>
[quoted text clipped - 10 lines]
> definition.  You'd think that it means lower calories, but lower calories
> than what?

One would assume less than their other foods. I managed to find some numbers
last night on their mainstream foods, which average about between 325-->400
kcal/cup.

>> (although the feeding
>> guide they have in the clinic suggests closer to 4 1/2 cups/day... I was
[quoted text clipped - 3 lines]
> the
> bag, opting to go on the basis of look and feel.

I know, he's always eaten more than any of his littermates (we chat
sometimes on a web discussion board). That is however what has always been
required for him to maintain his weight. He's a very muscular, quite active
lab, ideal weight is probably about 75->77 pounds (I'm shooting for the low
end due to joint issues). I tried feeding based on the bag once... he got to
be a bit too skinny, so we upped him to what he'd always been getting.

My rule as far as weight goes, is you should be able to feel the ribs
(without digging) but not see them. Right now, you do have to dig a very
small bit. I'm guessing if he were to loose about 5-7 pounds he should be
about right.

Dale
buglady - 18 Jan 2008 03:16 GMT
He's hypothyroid and Cushingoid,

.......well, when did that happen???  You finally got a diagnosis?  Speak!

buglady
take out the dog before replying
Suja - 18 Jan 2008 03:48 GMT
"buglady" <buglady99@bigfootdog.com> wrote in message:

> .......well, when did that happen???  You finally got a diagnosis?  Speak!

Didn't I post about it?  I thought I had.

Khan has been treated for hypothyroidism since 2006.  Early last year, he
broke a tooth, and in the pre-anesthetic work-up, the vet noticed the dilute
urine, which led to the series of tests which led to the IM consult and
ultrasound, which led to the Tennessee panel, and the verdict that he has
Atypical Cushing's.  He has been treated for it since about June of 2007.
Huge improvements in coat condition, in that he's no longer balding,
although the rat-tail is taking a long time to recover, and is nowhere near
normal for him.  As of his yearly physical in October, the urine specific
gravity had gone from 1.015 to 1.023.  He is no longer drinking/peeing
excessively.  Skin condition has improved, but not to either the vet's of my
satisfaction, so we are not quite sure what to do yet, but another TN panel
is probably in his future.  I need to pick Dr. Oliver's (the UTenn
endocrinologist) brain about it a bit to see if we need to explore other
options for treatment.

One interesting finding was that although his blood work-up was done
fasting, and therefore without his morning thyroid meds, the two thyroid
values came back in the middle of the range, which they usually aren't, even
with meds (always low-normal, always), so it is possible he isn't really
hypothyroid at all, and it was a function of the Cushing's.  His regular vet
is on maternity leave, so we'll probably not go back for some time, but the
next time we're back, I'm having another full Thyroid panel done at MSU to
see where his levels are, and see if we can take him off the thyroid meds.
I was kinda hoping that if his urine is concentrating again, we can wean him
off the Proin too, but the last attempt did not work at all.

Suja
buglady - 18 Jan 2008 16:04 GMT
> Didn't I post about it?  I thought I had.
>
[quoted text clipped - 3 lines]
> ultrasound, which led to the Tennessee panel, and the verdict that he has
> Atypical Cushing's.  He has been treated for it since about June of 2007.

.......Nope, I don't think you did, unless I was asleep or dead.  And thanks
for the update.  What the heck is atypical Cushings?  A feedback problem?
And what are they treating with, I'm assuming nothing so drastic as
Lysodren?

......I'm glad you finally got an answer to this brain twister.

> One interesting finding was that although his blood work-up was done
> fasting, and therefore without his morning thyroid meds, the two thyroid
> values came back in the middle of the range, which they usually aren't, even
> with meds (always low-normal, always), so it is possible he isn't really
> hypothyroid at all, and it was a function of the Cushing's.

........Interesting huh!  There's that euthyroid sick again.  Now you know
what that means!

buglady
take out the dog before replying
Suja - 18 Jan 2008 20:20 GMT
"buglady" <buglady99@bigfootdog.com> wrote in message:

> What the heck is atypical Cushings?

It's similar to regular Cushing's, except instead of being mediated by
cortisol, this is mediated by adrenocortical sex hormones and their
precursors.  The testing is similar to an ACTH stim test, except that in
this case, in addition to measuring the cortisol levels, they also measure
the levels of sex hormones.  Of the top of my head, the ones measured are
progesterone, estradiol, androstenedione, 17 OH progesterone and
aldosterone.  I thought the test measured 7 hormones, not 5, so I'm probably
missing a couple.

Khan had a single abnormal result on the panel, which neither our IM vet nor
our regular vet had seen.  His androstenedione was elevated both pre and
post.  Pre - 4.1 where 3.6 is high normal and Post - 62 where 29 is high
normal.

> A feedback problem?

They don't really know, unfortunately.  Something in the look/cascade has
gone wrong, but we don't know what exactly.

> And what are they treating with, I'm assuming nothing so drastic as
> Lysodren?

Current treatment protocol for normal Cushing's involves Lysodren or
Trilostane, but the one for Atypical isn't nearly as drastic.  He is on
melatonin 3 mg. 2x a day and Flax Seed Oil with lignans 1 x a day.  I'm
changing the FSO to purified lignans (40 mg) 1x a day to see if it makes any
difference.  There is also the option of using a melatonin implant, but it
normally lasts only 3 - 4 months, and I'm not sure if it is worthwhile.

> ........Interesting huh!  There's that euthyroid sick again.  Now you know
> what that means!

Yup.  I know a few others whose dogs seem to be responding similarly, so
there appears to be a connection there for sure.

Suja

P.S.  Sorry Dale, for the thread drift.
buglady - 18 Jan 2008 20:50 GMT
> P.S.  Sorry Dale, for the thread drift.

........aw, he's a vet student.......ALL is gravy!  Thanks again!

buglady
take out the dog before replying
Dale Atkin - 17 Jan 2008 15:12 GMT
> First, check the actual calorie content of current food vs old food.  You
> can usually do that online at the company's website.  Make sure you aren't
[quoted text clipped - 9 lines]
>
> Deborah, DVM

Would mucussy vomit fit with any of these theories? There was plenty of food
in there too, (although it was a little more digested than I would have
expected given the time since he'd eaten)

Thoughts?

Dale
 
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