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Pet Forum / Miscellaneous / Animal Health / September 2008carboplatin
Anyone here tell me anything about the use of carboplatin for treatment of inoperable cancers? Can the average vet use this for treatment? > Anyone here tell me anything about the use of carboplatin for treatment > of inoperable cancers? Can the average vet use this for treatment? > Carboplatin's purpose isn't for "inoperable cancers." Some cancers are sensitive to it, though. The ones I can think of right now are sarcomas, such as osteosarcoma and soft tissue sarcomas. Carboplatin can be used by general practitioners if (s)he is comfortable with chemotherapeutic medications, the associated monitoring and treatment of possible adverse effects. Personally, I've used carbo on one patient after a limb amputation for bone cancer. The treatment is usually given several times over a 1.5 month period or so. The great thing about it is that it's much less likely to cause kidney failure than cisplatin, it's cousin. The bad thing is that it's very expensive. Sandy, DVM Thanks for the information. How does this compare to radiation treatment in terms of expense; is the primary expense in the cost of the drug or the anesthesia? In this case it would be injected directly into the tumor. By being "comfortable with" what do you mean? >> Anyone here tell me anything about the use of carboplatin for >> treatment of inoperable cancers? Can the average vet use this for [quoted text clipped - 13 lines] > > Sandy, DVM > Thanks for the information. How does this compare to radiation > treatment in terms of expense; I'd guess carboplatin treatment is less expensive than full-course radiation therapy, although it may be more expensive than palliative radiation therapy. Understand, though, that the choice isn't usually carbo vs. radiation. I don't know exactly what cancer you're asking about, but depending on the tumor, the choices for treatment will vary. > is the primary expense in the cost > of the drug or the anesthesia? There is no anesthesia costs with carboplatin use. The drug is very expensive. > In this case it would be injected > directly into the tumor. By being "comfortable with" what do you mean? > Carboplatin isn't injected into tumor. Now, if you're talking about carboplatin *beads*, then that's a completely different ball game, so ignore all I've said in this thread. These are little dissolving beads that are coated with carboplatin so that the drug is slowly released into the local area of a tumor. It's used only in cases of soft tissue sarcomas, as far as I know. It's a very new treatment for animals, so I can't tell you how that treatment compares to radiation therapy post-operatively. There are no general practitioners using these beads. Our local oncologist is still trying to figure out the best way to get them into tumors for those pets not undergoing surgery, where they can be placed where they want to put them. Wendy, I really think you should be talking to your primary care veterinarian or your pet's oncologist about these specifics. I feel that I may just be confusing the matter because I don't have all the information and you're still learning what needs to be done for your pup. Sandy, DVM > >> [quoted text clipped - 18 lines] >> >> >> Thanks for the information. How does this compare to radiation >> treatment in terms of expense; [quoted text clipped - 23 lines] > to get them into tumors for those pets not undergoing surgery, where > they can be placed where they want to put them. No I am talking about a treatment that was used since the early 90's, using injections of sesame seed oil/carboplatin injected, in this case, into a squamous cell carcinoma tumor of the nose of cats. See: Intratumoral administration of carboplatin for treatment of squamous cell carcinomas of the nasal plane in cats. AJVR, v57, No. 2, Feb. 1996. It requires anesthesia for the injections, which means that this treatment may be as expensive or more so than radiation. I was just wondering if the average vet could do this procedure. Has a fairly high percentage response rate. We have alot of vets here who say they are full service, but they are afraid to do much beyond the simple stuff. > Wendy, I really think you should be talking to your primary care > veterinarian or your pet's oncologist about these specifics. I feel > that I may just be confusing the matter because I don't have all the > information and you're still learning what needs to be done for your > pup. not a pup, a cat. > Sandy, DVM >> [quoted text clipped - 22 lines] >> >> Interesting abstract from 1996. I'm not saying I'm an expert, but I haven't heard of any oncologists using this technique, Wendy. Was this treatment suggested to you an an option for your kitty? I would imagine it's less expensive than radiation therapy, but I can't compare survival rates or disease free intervals. Best of luck with a difficult disease. Sandy, DVM > No I am talking about a treatment that was used since the early 90's, > using injections of sesame seed oil/carboplatin injected, in this case, [quoted text clipped - 6 lines] > percentage response rate. We have alot of vets here who say they are > full service, but they are afraid to do much beyond the simple stuff. |
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